Research To Read, Edition 7.
In the seventh edition of Research To Read, let’s read some more research papers related to Neurology, the medical branch of study for the disorders of the nervous system, including the brain, spinal cord, and peripheral nerves.
What is the R2R newsletter all about?
To recap, this newsletter is my 2025 resolution in action: to make reading medical research a consistent habit. Just like any muscle that needs regular exercise, the only way to strengthen this practice is by doing it repeatedly.
That’s the motivation behind Research to Read. It's a way for me to share the research I’m diving into, while also expanding my own knowledge. And I’m inviting my fellow medicos to join me on this journey. We all stand to benefit from staying informed and sharpening our understanding of the latest studies in our field.
So, let’s get into the research, together!
Before you dive in:
Here’s my list of research papers to read:
Kidney Impairment and α-Synucleinopathy: Implications for Assessment and Treatment
Lepkowsky, Charles. (2025). Kidney Impairment and α-Synucleinopathy: Implications for Assessment and Treatment. The American Journal of Geriatric Psychiatry: Open Science, Education, and Practice.
Parkinson’s disease and other Lewy body diseases like Alzheimer’s disease, alpha-synucleopathy etc. are progressive diseases that are high burden and increase healthcare costs for the population, with an impact on both patients and caregivers.
Previous studies have shown links between the enteric system and the CNS, and this study in the same vein, explores the link between the renal system and α-synucleopathies. This paper goes on to expand on the Universal Migration Hypothesis, the three-step pathway and how this knowledge could lead to better multisystem interventions.
Read it here: https://www.sciencedirect.com/science/article/pii/S2950386825000267
2. Prognostic impact of the number and total tumor burden of secondary cerebral lesions in patients with resected brain metastases of non–small cell lung cancers
Sauvageot S, Mollevi C, Thomas QD, Charissoux M, Darlix A, Rigau V, Bauchet L, Quantin X, Pujol JL, Roch B, Boetto J. Prognostic impact of the number and total tumor burden of secondary cerebral lesions in patients with resected brain metastases of non-small cell lung cancers. J Neurosurg. 2024 Jan 19;141(1):89-99.
This is a 2024 retrospective study of 184 patients with brain metastasis for non-small cell lung cancer from 2015 to 2021. It showed that factors such as TTB (total tumor burden), a high number of brain metastases, and residual tumour post-surgery are independent negative indicators of survival.
This shows that surgery is not just a functional but also a diagnostic tool, and also changes the perception of brain metastases as a lethal disease to a chronic neurological battle to maintain quality of life in these patients.
Read it here: https://thejns.org/view/journals/j-neurosurg/141/1/article-p89.xml
3. Stem cell therapy for Parkinson’s disease: A new hope for neural regeneration
Mokhtari YG, Varnava I, Kyrgiannis K, Ampatsidou V, Giakoumettis D. Stem cell therapy for Parkinson's disease: A new hope for neural regeneration. World J Biol Chem. 2025 Jun 5;16(2):106850.
…and that brings us to the end of the seventh edition of Research to Read!!
I hope you enjoyed it and look forward to reading more research along with me, where I’ll be diving into research rooted in different medical specialities :)
Check out Research to Read, Edition 1, Research to Read Edition 2, Research to Read Edition 3, Research to Read Edition 4, Research to Read Edition 5 and Research to Read Edition 6 here.
To get updates on future newsletter editions, please subscribe, and if you have any suggestions, write to me at srinivasannanditha@gmail.com
